睡眠特征与生物衰老风险之间的关联:基于157 227例病例和179 332例对照的孟德尔随机化研究
Mei Wang1, Meiqi Yang1, Shuang Liang1
1Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Sleep
|November 20, 2023
概括
优化睡眠时间和优先考虑早晨的时刻型可以帮助减缓生物衰老. 短时间和长时间的睡眠都会增加加速衰老的风险,强调睡眠时间.
科学领域:
- 遗传学和衰老研究研究
- 睡眠医学 睡眠医学
- 衰老的生物标志物
背景情况:
- 生物衰老是一个复杂的过程,可以受到各种生活方式因素的影响.
- 加快的生物衰老与与年龄相关疾病的风险增加有关.
- 睡眠是一个基本的生物过程,对衰老有潜在的影响.
研究的目的:
- 研究睡眠特征与加速生物衰老的风险之间的关联.
- 使用孟德尔随机化 (MR) 分析探索潜在的因果关系.
- 为了确定减轻生物衰老的最佳睡眠模式.
主要方法:
- 利用来自336,559名参与者的英国生物库数据,包括加速生物衰老 (PhenoAgeAccel) 和对照病例.
- 员工倾向得分匹配和有条件的多变量逻辑回归来估计关联.
- 应用线性和非线性孟德尔随机化方法来评估睡眠特征和PhenoAgeAccel之间的因果关系.
主要成果:
- 在睡眠时间和PhenoAgeAccel风险之间观察到一个U形的关联;与正常睡眠者 (6-8小时) 相比,短时间和长时间睡眠者表现出更高的风险.
- 晚上时代型与更高的PhenoAgeAccel风险有关,而早晨时代型显示出保护作用.
- 门德尔随机化分析证实了基因预测的睡眠时间和PhenoAgeAccel之间的非线性U形关系.
结论:
- 优化睡眠时间和时间型可能是减缓生物衰老的可行策略.
- 这些发现突显了睡眠调节作为减少衰老不良影响的干预措施的潜力.
- 对睡眠干预措施的进一步研究可能为促进健康衰老提供新的方法.
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