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化合物益生菌可以通过影响 brojlers 的肠道微生物群来改善肠道健康
Xuan Liu1, Zhenhua Ma1, Yanfei Wang1
1Shanxi Key Laboratory for the Modernization of TCVM, College of Life and Science, Shanxi Agricultural University, Taigu 030801, Shanxi, China.
Journal of animal science
|November 20, 2023
概括
这项研究表明,复合益生菌显著改善肉生长,肠道屏障功能和有益的肠道细菌. 益生菌还可以减少有害细菌,在家禽养殖中为抗生素提供了有价值的替代品.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 在家禽生产中使用抗生素正面临越来越多的审查和监管.
- 益生菌为改善动物健康和表现提供了抗生素的潜在替代品.
- 了解益生菌对肉生理和肠道微生物群的具体影响至关重要.
研究的目的:
- 评估化合物益生菌对Arbor Acres肉生长性能,尸体特征,肠道屏障功能和免疫反应的影响.
- 分析由益生菌补充引起的肠道微生物群组成和功能的变化.
- 为在肉生产中应用益生菌提供理论基础.
主要方法:
- 四百八十只肉被分为四组:对照组 (基础饮食) 和三组益生菌治疗组 (1,5,10克/公斤化合物益生菌).
- 测量了生长性能,尸体特征,肠道屏障基因表达 (Claudin,Occludin,MUC2,ZO-1),以及免疫基因表达 (TLR2,TLR4,IL-1β,IL-2).
- 进行了16S rDNA amplicon测序和PICRUSt2功能分析,以评估肠道微生物群的组成和潜在功能.
主要成果:
- 与对照组相比,益生菌补充剂,特别是10g/kg (益生菌III组),显著改善了 brojiler生长性能和尸体特征.
- 肠道屏障相关的基因表达增加,早期免疫基因表达在益生菌组上调,益生菌III组的影响最为显著.
- 益生菌的管理改变了肠道微生物群,增加了有益的细菌 (例如,Bacteroidales,Alistipes) 和减少有害的细菌 (例如,蛋白质细菌),在DNA复制,转录和糖解中具有丰富的功能.
结论:
- 化合物益生菌有效地提高肉生长,肠道屏障完整性和免疫状态.
- 益生菌调节肠道微生物群的组成,促进有益的微生物,抑制有害的微生物.
- 这项研究支持使用益生菌作为一种可行的策略,以改善肉生产性能和肠道健康,作为抗生素增长促进剂的替代品.
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