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克服使用聚合物微针来通过皮肤和皮肤传递草药疗法的挑战
Anusha V M1, Sarasija Suresh1, Avichal Kumar2
1Institute for Drug Delivery and Biomedical Research, Bengaluru, India.
Journal of biomaterials science. Polymer edition
|November 20, 2023
概括
聚合物微针提供了一种新的方法,可以通过皮肤传递草药疗法 (HT),克服生物可用性挑战. 这项技术在治疗各种疾病和帮助诊断方面表现有前途.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 自然产品因毒性低而受到青,但草药疗法 (HT) 由于溶解性,透性和稳定性问题,经常面临口服生物可用性差.
- 通过皮肤输送提供了一个解决方案,导致成功的草药通过皮肤产品.
- 聚合物微针 (MNs) 是一个有前途的平台,可以克服在HT分娩中的皮肤屏障限制.
研究的目的:
- 审查聚合物微针 (MN) 技术的进步,以通过皮肤输送草药疗法 (HT).
- 突出MNs在治疗皮肤疾病,系统性疾病和美学问题中的应用.
- 探索MNs作为诊断工具的潜力,并讨论制定挑战.
主要方法:
- 对聚合物微针制造和草药疗法的应用现有文献的审查.
- 在MN建筑中使用的生物相容和生物降解聚合物的讨论.
- 分析MNs在皮肤,全身和美学交付以及诊断应用中的作用.
主要成果:
- 聚合物MN有效地增强HT的通过皮肤传递,解决生物可用性问题.
- MNs用于治疗皮肤疾病 (癌症,,伤口),系统性疾病 (喘,中枢神经系统) 和美学应用.
- 多种药物显示出作为生物标志物采样的最小侵入性诊断辅助剂的潜力.
结论:
- 聚合物微针技术为草药治疗提供了重大进步,提供了更好的生物可用性和多样化的应用.
- 制定HT的聚合物MN的挑战需要进一步的研究来优化其潜力.
- 未来的努力旨在扩大聚合物MN在草药治疗中的治疗和诊断应用.
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