扩散性胃肠道运动损害在患有硬质皮质症的患者:最小侵入性技术的实用性
Christian von Mühlenbrock1,2, Ana María Madrid3, Claudia Defilippi3
1Functional Digestive Diseases and Motility Laboratory, Gastroenterology Section, Hospital Clinico Universidad de Chile, Dr. Carlos Lorca 999, Independencia, Santiago, Chile. christianvon@uandes.cl.
Digestive diseases and sciences
|November 20, 2023
概括
胃肠道 (GI) 损害在硬化皮质患者中很常见,影响高达90%的人. 这项研究使用了最少的侵入性方法来评估胃肠道干扰,发现无论症状如何,它都很常见.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 系统性炎症性疾病 系统性炎症性疾病
背景情况:
- 硬化皮质经常影响多达90%的患者的胃肠道.
- 了解胃肠道损害的程度和性质对于患者管理至关重要.
研究的目的:
- 通过微创技术,在硬化肌病患者中表征食道,胃和肠道损伤.
- 调查肠道干预,症状和疾病严重程度之间的关联.
主要方法:
- 根据美国风湿病学学院的标准,招募了30名全身性硬化症患者.
- 采用了为期四天的方案:食道测量,肠道测量,电胃学和气呼吸测试.
- 使用曼-惠特尼和千二测试进行统计分析.
主要成果:
- 胃肠道损害的高患病率:80%的肠道,76%的食道,66%的细菌过度生长.
- 23%的人同时表现出食道,胃和肠道的参与.
- 胃肠道损害与皮肤参与相关,但与胃肠道症状没有直接关联.
结论:
- 胃肠道干扰是多发性硬皮病的常见并发症.
- 胃肠道损伤的存在在很大程度上独立于患者的症状和临床特征,除了皮肤的参与.
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