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患有青少年异常性关节炎的儿科患者的甲状腺功能
Mariella Valenzise1, Federica D'Amico2, Eleonora Tripodi2
1Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy. mvalenzise@unime.it.
Endocrine
|November 20, 2023
概括
患有青少年异常性关节炎 (JIA) 的儿童需要对甲状腺功能进行监测,特别是那些多关节形式的儿童,甲状腺变化和自身免疫性甲状腺疾病的发病率更高.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 青少年性异位性关节炎 (JIA) 是儿童的一种慢性炎症性疾病.
- 关于儿科JIA患者的相关自身免疫性疾病的数据有限.
- 甲状腺功能障碍是一种潜在的并发症,需要进行调查.
研究的目的:
- 为了评估被诊断患有JIA的意大利儿童的甲状腺功能.
- 在这个队列中识别与JIA相关的特定自身免疫甲状腺疾病 (ATD).
- 为了比较不同JIA亚型之间的甲状腺相关标志物.
主要方法:
- 51名JIA患者的临床评估,包括家庭和个人病史.
- 评估甲状腺功能测试 (甲状腺激素,TSH).
- 测量抗甲状腺抗体 (抗TPO,抗hTG) 和抗核抗体 (ANA).
主要成果:
- 多关节性JIA形式显示,与oligoarticular形式相比,抗TPO抗体的流行率显著更高 (p=0.032).
- 在多关节性JIA组 (p<0.05) 中观察到自免疫性疾病 (AD) 的家族病史的显著流行率.
- 在JIA亚型之间的性别流行,抗hTG或ANA之间没有发现显著差异.
结论:
- 甲状腺功能评估对于患有JIA的儿童至关重要.
- 多关节性JIA亚型具有更高的甲状腺功能变化的风险.
- 对于多关节性JIA患者,由于增加了ATDs风险,建议特别注意和监测.
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