人类免疫缺陷病毒作为心血管疾病的风险因素
Agnieszka Lembas1,2, Andrzej Załęski3,4, Michał Peller5
1Department of Infectious and Tropical Diseases and Hepatology, Medical University of Warsaw, Warsaw, Poland.
Cardiovascular toxicology
|November 20, 2023
概括
由于炎症和其他因素,艾滋病毒感染者 (PLWH) 面临更高的心血管疾病 (CVD) 风险,即使有有效的抗逆转录病毒疗法 (ART). 了解这些机制是管理这一群体中心血管疾病的关键.
科学领域:
- 心血管疾病研究研究
- 艾滋病毒 医学 艾滋病毒 医学
- 免疫学 免疫学 免疫学
背景情况:
- 艾滋病毒感染显著提高了艾滋病毒感染者 (PLWH) 心血管疾病 (CVD) 的风险.
- 增加的促炎分子水平 (例如IL-6,TNF-α,hs-CRP) 是艾滋病毒感染的特征.
- 诸如CD4+淋巴细胞枯竭,肠道透性增加和脂质代谢变化等机制有助于心血管疾病风险.
研究的目的:
- 审查PLWH中心血管疾病风险增加背后的机制.
- 评估艾滋病毒感染和抗逆转录病毒疗法 (ART) 对心血管疾病发展的影响.
- 强调将艾滋病毒视为心血管疾病的潜在因果因素的重要性.
主要方法:
- 关于艾滋病毒,炎症和心血管疾病研究的文献综述.
- 在PLWH中分析促炎性标志物.
- 检查ART和同时感染 (HCV,HBV) 在心血管疾病风险中的作用.
主要成果:
- 艾滋病毒感染与高水平的促炎性标志物有关,即使是ART,尽管ART降低了一些水平.
- 虽然ART的副作用有助于心血管疾病的风险,但HIV本身被认为是代谢综合征发展的一个更重要的因素.
- 吸烟和同时感染的更高患病率加剧了PLWH中心血管疾病的风险.
结论:
- 艾滋病毒在心血管疾病的发展中起着重要的作用,独立于传统的危险因素.
- 需要全面的管理策略来解决PLWH中CVD的问题.
- 早期考虑艾滋病毒作为心血管疾病因素至关重要,特别是在较年轻或不典型的病例中.
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