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青少年人类乳头瘤病毒疫苗接种多层次实施策略:一个集群随机临床试验

Lila J Finney Rutten¹, Joan M Griffin², Jennifer L St Sauver¹

¹Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.

JAMA pediatrics

|November 20, 2023

概括

将父母提醒与医疗保健专业人士反相结合,显著提高了青少年的人类乳头瘤病毒 (HPV) 疫苗接种率. 这种双重方法比通常的护理或个人干预措施更有效地提高了HPV疫苗接种率.

科学领域:

公共卫生公共卫生
预防医学预防医学
疫苗学疫苗学疫苗学

背景情况:

据估计,美国每年约有36,500例新发癌症与人类乳头瘤病毒 (HPV) 有关.
接种HPV疫苗仍低于国家公共卫生目标,落后于其他青少年疫苗.
需要有效的策略来提高HPV疫苗接种率.

研究的目的:

评估两个基于证据的干预措施对HPV疫苗接种率的单独和综合影响.
评估家长提醒/召回和医疗保健专业人员审计/反对11岁和12岁儿童接种HPV疫苗的有效性.

主要方法:

在6个初级保健实践中进行了一项随机集群临床试验,采用阶梯式因数设计.
干预措施包括家长提醒/召回和医疗保健专业人员审计/反,单独和组合评估.
分析了从2018年4月到2019年3月的数据,其中包括9,242名11-12岁的儿童.

主要成果:

父母提醒/召回和医疗保健专业人员审计/反的组合导致了最高的HPV疫苗接种率 (39.7%).
与常规护理 (21.9%) 相比,联合干预措施显著增加了接种HPV疫苗的几率 (OR,2.03;95%CI,1.44-2.85).
父母提醒/召回单独也增加了接种疫苗的几率 (OR,1.56;95% CI,1.23-1.97),而审计/反单独显示没有显著的差异.

结论:

同时实施父母提醒/召回和医疗保健专业人员审计/反是改善HPV疫苗接种率的有价值策略.
这些发现凸显了实现青少年疫苗接种公共卫生目标的多方面的方法的重要性.
优化HPV疫苗接种对于预防癌症至关重要.

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