人类疹病毒 8 干扰素调节因子 1 与 STAT3 和 Janus 激酶 TYK2 的直接和生物学意义上的相互作用

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Updated: Jul 10, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

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Zunlin Yang1, Qiwang Xiang1, John Nicholas1

  • 1Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

PLoS pathogens
|November 20, 2023
PubMed
概括

人类疹病毒8 (HHV-8) 使用vIRF-1 通过抑制TYK2来阻止STAT3信号传输,这对病毒复制至关重要. 这种相互作用也会影响vIRF-1的表达和病毒的产生.

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