增加了sub-Tenon注射的mitomycin C的trabeculectomy的手术结果
Bratislavske lekarske listy
|November 20, 2023
概括
带有线粒素C (MMC) 注射的垂眼切除术有效降低了青光眼患者的眼内压力 (IOP),减少了药物治疗的需要. 这种安全的手术方法显示了持续的IOP控制和长期改善的角膜参数.
科学领域:
- 眼科医生 眼科 眼科
- 手术创新 在外科创新.
- 青光眼治疗方法 青光眼治疗方法
背景情况:
- 用线粒素C (MMC) 注射到Tenon层的带切除术正在引起人们对玻璃眼治疗的关注.
- 有限的临床数据需要进一步研究其有效性和安全性.
研究的目的:
- 综合评估使用内内注射的MMC.的轨道切除术的有效性.
- 评估对眼内压力 (IOP) 和角膜参数的影响.
主要方法:
- 50名患者的50只眼睛接受了0.4毫克/毫升MMC (0.05毫升体积) 的轨道切除术.
- 主要终点:手术后1,8,30,90天和6,12个月内心压力控制.
- 二级终点:手术后90天角膜参数的变化.
主要成果:
- 平均手术前内血压 (32.34 ± 9.45 mmHg) 在手术后显著下降 (17.52 ± 4.58 mmHg 在90天,18.14 ± 3.74 在6个月,19.30 ± 3.82 在12个月).
- 平均抗光眼药物的使用量从3.50±0.74减少到0.58±1.03.
- 在角膜歇斯底里,前腔深度 (ACD) 和中央角膜内皮细胞数 (CECC) 中观察到显著的变化.
结论:
- 带有TENON内部MMC注射的轨道切除术是一种安全有效的开角玻璃眼的治疗方法.
- 该程序显示了显著的IOP降低效应.
- 手术后可以完全停止服用抗白血病药物.
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