在非常早产的婴儿中表观遗传加速年龄,新生儿疾病和神经行为特征
Uriel Paniagua1, Barry M Lester2,3,4, Carmen J Marsit1,5
1Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Epigenetics
|November 20, 2023
概括
非常早产的新生儿患有新生儿疾病,特别是支气管肺功能障碍 (BPD),表现出加速表观遗传衰老. 出生时较低的妊娠年龄可能是这些发现的一个潜在因素.
科学领域:
- 新生儿科学 新生儿科学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发育儿科 发育儿科
背景情况:
- 表观遗传衰老加速与慢性疾病和生物衰老有关.
- 过早出生的婴儿面临着更高的发育问题的风险.
- 关于早产婴儿新生儿早期表观遗传衰老的研究有限.
研究的目的:
- 为了研究非常早产婴儿的表观遗传加快年龄.
- 确定新生儿疾病,神经行为特征和表观遗传衰老之间的关联.
- 了解早期疾病或神经行为特征是否影响表观遗传衰老轨迹.
主要方法:
- 利用了新生儿神经行为和非常早产婴儿 (NOVI) 研究的结果数据 (n=519).
- 雇佣了一般化的估计方程来分析年龄加速.
- 检查了与重症新生儿疾病和神经行为评估的关系.
主要成果:
- 患有新生儿疾病的婴儿,特别是支气管肺形 (BPD),表现出加速表观遗传年龄.
- 一些证据表明,高度与增长的年龄加速,以及不对称的反射与减小年龄加速之间存在联系.
- 妊娠年龄调整部分解释了观察到的关联,表明妊娠时间的作用.
- 主要发现证实了新生儿发病率 (特别是BPD) 的非常早产婴儿的年龄加速.
结论:
- 非常早产的婴儿经历新生儿疾病,特别是BPD,表现出表观遗传加速年龄.
- 大多数新生儿神经行为特征和疾病与早期表观遗传衰老没有显著关联.
- 出生时较低的妊娠年龄似乎是影响这些表观遗传衰老模式的重要上游因素.
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