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脊髓脑膜瘤患者的流行病学和生存率:一项大型回顾性队列研究
Yang Wang1, Xiaoman Wang2, Tong Yu1
1Department of Orthopedics.
International journal of surgery (London, England)
|November 20, 2023
概括
脊髄膜瘤 (SMs) 是一种罕见的瘤,在老年人,特别是女性中发病率正在增加. 一个新的名图有助于预测存活率和分层死亡风险,用于个性化患者管理.
科学领域:
- 神经瘤学神经瘤学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 脊髄膜瘤 (SMs) 是一种罕见的中枢神经系统瘤,由于全球人口老龄化,其患病率越来越高.
- 这些瘤往往表现为神经症状,需要对其流行病学和预后有更深入的了解.
研究的目的:
- 进行脊柱脑膜瘤的系统流行病学和生存预后分析.
- 评估SMs对公共卫生的影响.
- 开发一种新的方法来估计MSS患者在3,5年和10年的总生存期.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库 (2000-2019) 中对5158名MS患者的分析.
- 描述性流行病学分析,然后随机分配到培训 (70%) 和验证 (30%) 集中.
- 卡普兰-梅尔法和考克斯回归以确定预后因素并构建名录;使用ROC和决策曲线分析进行评估;开发风险分层系统和动态名录.
主要成果:
- 自2004年以来,MS的发生率稳步增加,女性与男性的比例约为4:1.
- 受影响最大的年龄组是50-59岁,60-69岁和70-79岁.
- 确定了七个独立的预后因素,导致了具有高临床实用性和准确性的名图;风险分层系统有效地将患者分为低风险,中风险和高风险子组.
结论:
- 脊柱脑膜瘤是罕见的良性瘤,主要影响老年白人女性.
- 一个开发出来的名图允许个性化的生存预测,风险分层,以及SMs患者的知情决策.
- 基于网络的动态名录可以增强临床应用,患者咨询,监测和评估.
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