分隔式加压是超收缩食道的新奇预后因素
Andrew R Leopold1, Patrick McCarthy2, Anupama Nair1
1Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Neurogastroenterology and motility
|November 20, 2023
概括
在高收缩性食道 (HE) 中的分隔式加压 (CP) 与症状恶化和对医疗治疗的反应不佳有关. 在HE中确定CP可能会指导未来的治疗策略,以改善患者的治疗结果.
科学领域:
- 胃肠病学 胃肠病学
- 食道运动障碍 食道运动障碍
- 高分辨率食道测量仪 (HREM) 是一种高分辨率的食道测量仪.
背景情况:
- 过度收缩食道 (HE) 的特点是食道体收缩强度增加.
- 分隔式加压 (CP) 是一种以前未与高压相关研究的计量模式.
研究的目的:
- 研究HE患者中CP的患病率和临床意义.
- 确定CP是否影响HE患者的症状严重程度和治疗反应.
主要方法:
- 对830项HREM研究的回顾性审查.
- 使用芝加哥分类v4.0.0.的HE患者的识别.
- 分析CP状态,埃卡德得分 (ES) 和治疗结果.
主要成果:
- 在30名 (36.7%) 的HE患者中,有11名患者表现出CP.
- 患有CP的HE患者的ES呈现率更高 (7对4),并且更有可能与慢性阿片类药物使用有关 (36.4%对5.3%).
- 患有CP的HE患者对药物治疗没有反应,与没有CP的患者不同 (0%对显著缓解).
结论:
- 在HE患者中,CP与症状严重程度的增加有关.
- 在HE中CP表明缺乏对医疗治疗的反应.
- CP可以作为指导治疗决策的预后标记.
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