在体重不足的患者中,固剂量肝素定位胆片的安全性
Roxanne McKnight1, Mohammad Salameh2, Lee Ann Jones3
1Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA.
Thrombosis research
|November 20, 2023
概括
静脉血栓塞栓症 (VTE) 患者体重不足的固定剂量肝素定位胆剂并没有增加出血风险,但由于肝素相关值 (HCV) 高,更多体重不足的患者需要保持肝素. 需要进一步的研究.
科学领域:
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
背景情况:
- 静脉血栓塞栓症 (VTE) 治疗通常涉及肝素.
- 使用固定剂量定位玻尿酸的氨酸诺图,用于管理氨酸相关值 (HCV).
- 人们担心,在接受标准肝素定位剂量的体重不足患者中,出血风险增加.
研究的目的:
- 为了评估固定剂量肝素定位球体在患有静脉瘤的体重不足患者的安全性.
- 为了比较低体重和正常体重VTE患者之间的肝素相关值 (HCVs) 和出血事件.
主要方法:
- 追溯研究包括成人VTE患者需要肝素定位.
- 低体重患者 (BMI <18.5 kg/m2) 与对照组 (BMI 18.5-29.9 kg/m2) 进行了比较.
- 主要结局:在第一次标位玻尿酸后,患有超治疗性HCV的患者百分比;次要结局:肝素保持,HCV稳定时间和出血.
主要成果:
- 在第一次标位玻尿素 (13.9%在两组) 后,在超治疗性HCV中没有显著差异.
- 体重不足的患者更频繁地需要持有肝素输注.
- 两组之间没有观察到临床显著出血的差异.
- 所有患者需要超过48小时才能达到稳定的HCV.
结论:
- 与体重正常的患者相比,固定剂量肝素定位玻尿酸剂并没有导致超治疗性HCV或低体重VTE患者出血的发病率更高.
- 对出血风险的临床担忧仍然存在,原因是体重不足的患者更频繁地保持肝素.
- 需要进一步的研究,以充分评估低体重人群中肝素定位策略的安全性和有效性.
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