作为PFAS替代品和前体的多基酸 (PAP):概述
Junjie Ao1, Weifeng Tang1, Xiaoning Liu1
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Journal of hazardous materials
|November 20, 2023
概括
聚甲基酸 (PAP) 在产品中正在取代PFAS. 这些化学物质在体内转化为有害化合物,引发了安全问题,需要进一步研究.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 聚甲基酸盐 (PAP) 越来越多地被用作消费品中遗留的和聚甲基物质 (PFAS) 的替代品.
- 有关PAP的安全性存在担忧,因为它们在体内代谢成 perfluorooctanoic acid (PFOA) 和其他 perfluorinated carboxylates (PFCAs).
研究的目的:
- 审查目前关于PAPs的知识,重点关注它们的发生,人类暴露和毒性.
- 确定有关PAP的环境命运,暴露途径和健康影响的关键知识差距.
主要方法:
- 在各种环境矩阵和生物样本中对PAP的研究进行了全面的文献综述.
- 对毒动力学和毒理学数据的分析,包括流行病学和体外/体内研究.
主要成果:
- PAP在各种环境样本 (废水,尘埃,消费品) 中普遍存在,并在全球范围内检测到人体血液中.
- 6:2 diPAP和 8:2 diPAP是发现的最常见的PAP.
- PAPs在体内经历生物转化,产生潜在的有毒代谢物,并与内分泌干扰,氧化损伤和生殖毒性有关.
结论:
- 污染物是广泛存在的环境污染物,对人类有很大的暴露.
- 进一步的研究对于了解PAP的来源,命运,综合毒性,代谢物效应和混合暴露的风险至关重要.
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