肥胖是癌症发展的独立风险因素,在诊断出皮肤肌炎后
Astia Allenzara1, Nakisa Sadeghi2, Carolina Alvarez1
1University of North Carolina at Chapel Hill, Division of Rheumatology, Allergy and Immunology and Thurston Arthritis Research Center, Chapel Hill, NC, USA.
Seminars in arthritis and rheumatism
|November 20, 2023
概括
肥胖的皮肤肌肉炎患者面临患癌症的风险明显更高. 这项研究发现,肥胖在DM患者中增加了癌症几率的近两倍,突出了关键的联系.
科学领域:
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 皮质神经炎 (DM) 患者的癌症风险增加.
- 肥胖是一般人群中已知的癌症风险因素之一.
研究的目的:
- 为了调查肥胖和癌症发病之间的联系,在被诊断为皮肤肌肉神经炎的患者.
- 使用ICD代码和BMI数据,比较患有和没有肥胖的DM患者的癌症风险.
主要方法:
- 对12722名皮肤肌肉炎患者的回顾性分析.
- 使用后勤回归和时间到事件分析来评估癌症的几率和危险.
- 根据年龄和性别进行了调整.
主要成果:
- 被编码为肥胖的DM患者显示后续癌症的几率明显更高 (OR 1.98).
- 肥胖 (BMI ≥30 kg/m2) 与BMI定义的子组中增加癌症几率 (OR 1.23) 有关.
- 肥胖与16%的癌症风险增加有关 (aHR 1.16).
- 特定的癌症,如淋巴瘤,结肠直肠癌和癌在肥胖的DM患者中更为频繁.
结论:
- 肥胖与皮肤肌肉炎患者癌症风险增加独立相关.
- 研究结果表明,肥胖管理可能对DM癌症预防至关重要.
- 肥胖可能会影响DM患者观察到的特定类型的癌症.
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