在健康的男性人体中,在同情刺激期间,脏处理的动态变化
J C G Petersen1, T E N Jonassen1, N-H Holstein-Rathlou1
1Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Autonomic neuroscience : basic & clinical
|November 20, 2023
概括
通过下体负压 (LBNP) 增加了交感神经活动,增强了的保留,即使在干预结束后也会持续下去. 这项研究揭示了对分泌的持续作用,突出了对同情刺激的长期影响.
科学领域:
- 生理学 生理学 生理学
- 脏生理学 脏生理学
- 自主神经系统的自主神经系统
背景情况:
- 在交感神经活动升高期间,性再吸收的时间动态尚不清楚.
- 由下体负压 (LBNP) 诱导的中央低血压会激活气质受体反射来通过交感外流维持动脉血压.
- 这项研究研究了在受控的同情刺激下脏处理的时间过程.
研究的目的:
- 为了研究脏同情神经活动增加期间脏再吸收的时间反应.
- 为了确定脏保持率是否快速增加,保持升高,并在下体负压 (LBNP) 干预后恢复到基线.
主要方法:
- 30名健康的男性接受了90分钟的干预,包括 -15 mmHg LBNP, -30 mmHg LBNP, -15 mmHg LBNP与蛋白阻塞,或时间控制 (0 mmHg LBNP).
- 在干预期间,每15分钟收集一次尿液,并在康复后60分钟收集尿液,以评估脏反应.
- 测量了部分和远端的分泌量,以量化脏处理的变化.
主要成果:
- 所有干预组在90分钟的干预结束时都显示出远端分泌量有相似的减少.
- 尽管心血管参数,素和阿尔多素恢复到基线,但在干预后1小时内,分泌持续减少.
- -30 mmHg LBNP没有引起比 -15 mmHg LBNP更大的尿性反应,这表明和效应.
结论:
- 由LBNP诱导的交感神经活动增加,导致的再吸收迅速且持续增加.
- 在停止交感刺激和荷尔蒙和心血管参数的正常化后,观察到的分泌量的减少仍在继续.
- 需要进行进一步的研究,以探索长期缺乏分泌回收的机制.
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