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Updated: Jun 29, 2026

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定制分子识别在预先设计的多功能酶模仿氨酸打印接口中,以获得高亲和度和差异选择性;在肺癌患者中感知埃托波

Aqsa Tariq¹, Amina Arif², Muhammad Akram³

¹State Key Laboratory of Biobased Material and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, PO Box 250353, Jinan, Shandong, China; Interdisciplinary Research Center in Biomedical Materials (IRCBM), COMSATS University Islamabad (CUI), Lahore, 54000, Pakistan; Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.

Biosensors & bioelectronics

|November 20, 2023

概括

这项研究开发了一种新的纳米酶聚合物传感器,用于检测埃托化物 (ETO). 传感器表现出高特异性和选择性,使肺癌患者与健康个体的准确区分成为可能.

科学领域:

生物仿真传感器传感器
纳米材料是一种纳米材料.
聚合物化学聚合物化学

背景情况:

纳米酶提供了成本效益,但缺乏特异性.
分子印记聚合物 (MIP) 可以增强选择性.
结合纳米酶和MIP可以创建先进的传感接口.

研究的目的:

设计一个THPP@MIP接口,对乙氧化物 (ETO) 具有很高的亲和力和选择性.
开发一个便携式光学传感器用于ETO检测.
为了证明传感器在分辨癌症患者样本方面的能力.

主要方法:

用一个多功能5,10,15,20-tetrakis(4-hydroxyphenyl)-21H,23H-porphyrin (THPP) 纳米酶生长了MIPs.
在纤维素纸矩阵上创建了一个UV固化印制接口.
利用模仿酶的THPP@MIP接口通过TMB氧化进行ETO的光学检测.

主要成果:

对于ETO,THPP@MIP传感器实现了0.005-10μg mL−1的线性检测范围,检测极限为0.002μg mL−1.1.
对其他药物分子表现出显著的特异性和选择性.
成功分化了来自肺癌患者和健康志愿者的血清样本,通过HPLC/MS验证.

结论:

用预先设计的,模仿酶的纳米酶进行分子印记,可以创建高度选择性和特定的传感接口.
这种方法为宽频传感应用提供了一个通用平台.
开发的传感器显示出对临床诊断和药物监测的前景.

关键词:

癌症患者癌症患者模仿酶的酶模仿过程这种类型的Etoposide.分子印记是一种分子印记.氨酸是氨酸中的一种.预先设计的单体分子.

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