饮食摄入量与发生静脉血栓塞栓症之间的联系和途径
Yu Huang1, Yanjun Zhang1, Sisi Yang1
1Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Thrombosis and haemostasis
|November 20, 2023
概括
饮食中较高的摄入量与静脉血栓塞栓症 (VTE) 的风险较低有关. 肥胖和炎症标志物部分解释了这种保护性关联,这表明潜在的饮食干预措施可以预防VTE.
科学领域:
- 营养流行病学 营养流行病学
- 心血管健康 心血管健康
- 血栓形成研究研究
背景情况:
- 饮食中 (Mn) 与静脉血栓塞栓症 (VTE) 风险之间的关系尚未得到充分证实.
- 调查潜在的调解者,如肥胖,出血病和炎症,对于理解这种关联至关重要.
研究的目的:
- 检查饮食摄入量与发生静脉瘤风险之间的关联.
- 探索肥胖标志物,血液学参数和炎症生物标志物在Mn-VTE关系中的中介作用.
主要方法:
- 利用了202,507名没有基线VTE的成年人英国生物库数据.
- 通过在线24小时回忆 (Oxford WebQ) 评估的饮食摄入量.
- 发生的静脉血栓塞 (深静脉血栓和肺栓塞) 是主要结局,随访时间中位数为11.6年.
主要成果:
- 饮食中的摄入量与发生的VTE,DVT和PE有显著的反向关联.
- 肥胖指标 (BMI,腰围) 在很大程度上调解了这一关联 (36.0%,36.5%).
- 炎症生物标志物 (CRP,WBC) 和RDW也显著调解了这种关联,而MPV和PLT则没有.
结论:
- 饮食中摄入的与发生的VTE相反相关.
- 肥胖,炎症生物标志物和RDW是这种关系中的关键调解者.
- 发现是产生假设的,需要在多种不同人群中进一步验证.
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