波动神经功能障碍在COVID-19后的状态:一个试点横截面研究
Gemma Lladós1, Marta Massanella2, Roser Coll-Fernández3
1Department of Infectious Diseases, Germans Trias Long-COVID Unit, Fundació Lluita contra les Infeccions, Hospital Universitari Germans Trias i Pujol, Campus Can Ruti, Badalona, Spain; Red Española de la Investigación en COVID Persistente (REiCOP), Madrid, Spain; Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
概括
后COVID-19条件 (PCC) 涉及迷走神经和神经功能障碍,影响多个身体系统. 这项研究在PCC患者中发现了神经损伤和呼吸道肌肉衰弱的证据,这表明多因素的原因.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 胃肠病学 胃肠病学
背景情况:
- 后COVID-19状态 (PCC) 影响到COVID-19幸存者的5-10%.
- 迷走神经功能障碍是各种PCC症状的潜在原因.
研究的目的:
- 为了研究PCC患者的迷走神经和神经功能.
- 为了确定PCC的潜在病理生理机制.
主要方法:
- 跨部分试点研究比较PCC患者 (n=30) 与康复的COVID-19患者 (n=14) 和对照人群 (n=16).
- 通过超声波评估迷走神经结构/功能,并评估呼吸肌肉强度 (吸气压).
主要成果:
- 患有PCC的患者表现出迷走神经变厚,围心静止减少,反流/率增加.
- 显著的隔膜平和降低的吸入压力表明呼吸肌肉软弱.
- 研究结果表明,迷走神经和神经参与了PCC.
结论:
- 神经和神经功能障碍是PCC病理生理学的关键因素.
- PCC是一种复杂的综合征,具有多因素的起源.
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