在亨廷顿病的痴迷强迫和坚持性行为
Shayan Abdollah Zadegan1, Luke Kupcha2, Jorge Patino1
1Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Huntington's Disease Society of America (HDSA) Center of Excellence at the University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Behavioural brain research
|November 20, 2023
概括
亨廷顿病 (HD) 患者经常表现出强迫症和执着性行为 (OCB / PB). 当前的研究不一致地区分了OCB/PB,阻碍了对HD中这些显著症状的准确评估和理解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 强迫症和坚持性行为 (OCBs/PBs) 在亨廷顿病 (HD) 中很常见.
- 现有的研究往往无法将OCB与PB区分开来,导致报告不一致.
- 高达50%的运动表现性HD患者经历了OCBs.
研究的目的:
- 探索对亨廷顿病中OCB/PBs的评估和报告中的不一致性.
- 将现有的关于OCBs/PBs的证据集映射到HD.
- 突出需要更明确的诊断标准和评估工具.
主要方法:
- 对评估OCBs/PBs在亨廷顿病中的研究的文献综述.
- 分析报告当前研究中的不一致性.
- 审查OCB/PB的评估工具,例如问题行为评估 - 简单形式 (PBA-s).
主要成果:
- 在HD中单独报告PB是不常见的,通常与强迫症症状组合在一起.
- 评级表中的结构限制和重叠的定义有助于混合报告.
- 持久性行为项目存在于一些工具中,但经常被报告为复合分数.
结论:
- 在HD中对OCBs/PBs的不一致评估使得临床理解和管理变得复杂.
- 在HD中,PB与显著的心理痛苦,身体效应和高风险行为有关.
- 改善PBs的识别和监测对于早期检测和区分HD患者的疾病至关重要.
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