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对患有生长激素缺乏症儿童低频波动幅度的动态分析

Jurong Ding¹, Qiang Chen¹, Yihong Liu¹

¹School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, PR China; Artificial Intelligence Key Laboratory of Sichuan Province, Sichuan University of Science and Engineering, Zigong, PR China.

Behavioural brain research

|November 20, 2023

概括

患有生长激素缺乏症 (GHD) 的儿童表现出改变的动态局部大脑活动,特别是在前额,部和部区域. 这一发现增强了对GHD的理解.

科学领域:

神经科学是一个神经科学.
儿科儿科儿科
内分泌学在内分泌学.

背景情况:

增长激素 (GH) 对于生长,发育至关重要,并影响认知功能.
生长激素缺乏 (GHD) 是儿童病理性矮身的常见原因.
以前的研究表明,GHD可能会影响大脑活动和认知过程.

研究的目的:

研究被诊断患有GHD的儿童的动态局部大脑活动.
探索GHD和功能性大脑变化之间的关系.

主要方法:

使用休息状态功能磁共振成像 (fMRI).
应用低频波动幅度 (ALFF) 和滑动窗技术.
分析了26名患有GHD的儿童和15名健康对照 (HC) 的数据.

主要成果:

在大脑广泛区域的动态ALFF中发现了显著的异常时间变异性.
观察到这些异常主要发生在GHD儿童的前额环,环和叶.
在GHD中证明了改变自发大脑活动模式.

结论:

动态ALFF (dALFF) 有效地捕捉与认知和行为相关的自发大脑活动变化.
这些发现提供了对儿童GHD背后的病理生理机制的见解.
突出了GHD对大脑功能的影响,超出了身体成长.

关键词:

低频波动的幅度低频波动的幅度动态分析动态分析增长激素缺乏症增长激素缺乏症一个滑动窗口.

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