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来自Saposhnikovia divaricatee (土耳其语) 的多糖的结构特征. 具有抗过敏和抗氧化活性的schischk

Guang Xu¹, Ming Qin¹, Mengqi Yu¹

¹Key Laboratory of TCM-information Engineer of State Administration of TCM, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, PR China.

Journal of ethnopharmacology

|November 20, 2023

概括

从Saposhnikovia divaricatee中分离出一种新型的多糖体SP-3,并显示出显著的抗过敏和抗氧化作用. 这种化合物在治疗过敏反应和氧化压力方面具有治疗应用的潜力.

科学领域:

植物化学植物化学
免疫学免疫学免疫学
老年学是一门学科.

背景情况:

萨波什尼科维亚 (Saposhnikoviae Radix,来自*Saposhnikovia divaricatee*),是一种中国传统医药.
它传统上用于治疗感冒,头痛和皮肤.

研究的目的:

为了识别和描述来自 *Saposhnikovia divaricatee* 的新型活性多糖.
为了评估这些多糖的抗过敏和抗氧化生物活性.

主要方法:

使用PMP-HPLC,甲基化分析,酸解和NMR阐明多糖体结构.
使用RBL-2H3细胞进行体外抗过敏测试.
使用*C. elegans*模型进行体内抗氧化剂测定.

主要成果:

一种新的同质多糖体SP-3被净化,其分子量为3.096 × 104 Da.
SP-3由曼诺斯,拉姆诺斯,银河酸,葡萄糖,银河糖和阿拉比诺斯组成.
SP-3抑制了过敏性炎症因素,并增强了*C. elegans*的抗氧化能力,可能是通过SOD-3激活.

结论:

从Saposhnikovia divaricatee*中发现了一种新型的多糖体SP-3.
SP-3 具有显著的抗过敏和抗氧化特性.
这种多糖具有开发新治疗剂的潜力.

关键词:

抗过敏的抗过敏的抗氧化剂是一种抗氧化剂.它是一种多糖化合物.萨波什尼科维亚·迪瓦里卡蒂 (土耳其语) 这就是Schischkk.结构性表征结构性表征

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