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确定肠道微生物群和中风和中风后的功能组成部分的失调概况

Duncan Wei¹, Xiaopu Chen², Jing Xu¹

¹Department of Pharmacy, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, P. R. China.

Brain and behavior

|November 20, 2023

概括

肠道微生物群的改变与中风和中风后有关. 这项研究确定了与这些疾病相关的特定微生物变化和功能途径,提供了潜在的诊断生物标志物.

科学领域:

微生物组研究的研究.
神经学神经学
胃肠病学胃肠病学

背景情况:

脑卒中 (STR) 影响11.5%的患者在5年内患有脑卒中后 (PSE).
肠道微生物群的代谢物影响人类健康.
肠道微生物群在STR和PSE中的作用尚不清楚.

研究的目的:

确定STR和PSE中的肠道微生物群和功能组件.
提供STR和PSE诊断和治疗的基础.
调查肠道疾病和STR/PSE之间的关联.

主要方法:

从19名健康对照组,27名STR患者和20名PSE患者收集了便样本.
进行了16S rRNA基因测序和安普利康序列变异分析.
分析了社区的多样性,主导物种和功能途径.

主要成果:

在STR和PSE患者的肠道微生物多样性减少.
确定了特定的细菌变化:STR中的Enterococcus增加,PSE中的Escherichia Shigella和Clostridium无菌组增加,PSE中的Faecalibacterium减少,以及两者中的Anaerostipes减少.
发现了潜在的生物标志物:STR的Butyricicoccus,PSE的Faecalibacterium,以及NK4A214_group和Veillonella的两个.
发现了改变的代谢途径:STR中的l-三丹生物合成,PSE中的脂肪酸生物合成,以及两者中的耐压/无氧功能.

结论:

被扰乱的肠道微生物群和相关的功能失调与STR和PSE的进展有关.
特定的微生物形状和代谢途径可以作为诊断指标.
结果表明肠道微生物群调节作为STR和PSE的治疗点.

关键词:

诊断诊断诊断诊断诊断诊断功能功能功能功能.肠道微生物群物种的种类.在中风后的发作.一次性中风中风中风中风中风

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