基于希夫基和键的pH响应,可注射和自我愈合的奇托桑-胺水凝
Haolei Shi1, Dongxu Ma1, Di Wu2
1Engineering Research Center of Advanced Wooden Materials, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China.
International journal of biological macromolecules
|November 20, 2023
概括
这项研究开发了一种智能水凝,用于控制药物输送. 适应pH值,可注射和自我愈合的奇多-氨酸水凝有效释放出克西福林,没有细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 智能水凝为疾病治疗提供局部和受控的药物释放.
- 桑和氨酸是开发先进水凝的多功能材料.
研究的目的:
- 为了创建一个pH响应,可注射和自我愈合的水凝,用于控制的taxifolin释放.
- 为了研究基托桑-库马林 (CS-CA) 水凝的特性和性能.
主要方法:
- 通过结解和基托和氨酸的光交联合成了水凝.
- 描述包括压力强度,自我愈合效率和体外药物释放研究.
- 用CCK8测定和小鼠皮下植入来评估细胞毒性和生物降解性.
主要成果:
- 该CS-CA水凝表现出高压力强度 (1.04 MPa) 和出色的自我愈合效率 (99.9%).
- 在注射后,水凝保持了结构完整性,并且根据pH值显示可调节的taxifolin释放.
- 与性pH (pH 9.2) 相比,在酸性pH (pH 4) 时,taxifolin的释放显著更高.
- 水凝没有表现出细胞毒性,并且在体内具有良好的生物降解性和生物相容性.
结论:
- 开发的CS-CA水凝是一种有前途的智能材料,用于控制和局部药物输送.
- 它的pH响应,可注射和自我愈合特性使其适用于先进的治疗应用.
- 该材料显示出出色的生物相容性和生物降解性,支持其在生物医学领域的潜在应用.
相关概念视频
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