通过半固体挤出实现个性化药物输送:探索聚乙烯醇-联合乙烯酸乙酸) kopo 聚合物用于含基化物载入的薄膜
Karin Korelc1, Bjarke Strøm Larsen1, Anna-Lena Heintze2
1Department of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, Oslo 0316, Norway.
概括
定制聚乙烯醇-联合乙乙酸) (PVA/PVAc) 共聚合物比率可以实现个性化的药物输送膜. 调整单体比率可以有效调整甲酸 (HCT) 的释放和透性,而更高的乙烯基酒精含量可以增强药物释放.
科学领域:
- 聚合物科学和材料科学
- 制药科学 制药科学
- 药物输送系统是药物输送系统.
背景情况:
- 个性化药物递送需要具有可调节性质的系统.
- 聚乙烯醇-联合乙乙酸) (PVA/PVAc) 共聚合物通过单体比率的修改提供可调性特性.
- 甲 (HCT) 由于溶解性差,点高和透性低,因此存在配方挑战.
研究的目的:
- 研究PVA/PVAc共聚合物的不同乙烯醇 (VA) 和乙烯酸乙烯 (VAc) 单体比对酸 (HCT) 薄膜的特性的影响.
- 评估半固体挤出用于制备HCT-PVA/PVAc薄膜的适用性.
- 评估开发的HCT膜的药物分布,释放动力学,透性和细胞毒性.
主要方法:
- 制备五种具有不同的VA/VAc比率的PVA/PVAc共聚合物.
- 对共聚合物的特性进行表征.
- 使用半固体挤出制造HCT-PVA/PVAc薄膜.
- 药物分销的同质性评估.
- 在体外药物释放研究.
- 使用HT29-MTX细胞单层的透性研究.
- 细胞毒性测定.细胞毒性测定.
主要成果:
- 所有测试的PVA/PVAc共聚合物都适合半固体挤出,具有更高的VA比例,产生更好的机械性能.
- 甲在微米级的膜内均分布.
- VA/VAc单体比率显著影响了HCT释放率,较高的VA含量导致释放增加.
- 在不同配方中观察到不同的HCT透性.
- 在任何测试的HCT-PVA/PVAc配方中都没有检测到细胞毒性.
结论:
- 聚乙烯/PVAc共聚合物的单体比是决定薄膜特性,药物释放和透性的关键因素.
- 半固体挤出是一种生产HCT-PVA/PVAc薄膜的可行方法,解决了与HCT相关的挑战.
- 由于PVA/PVAc共聚合物的可调性,可以方便个性化药物输送,允许灵活的剂量和有吸引力的剂型设计,特别适用于儿科应用.
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