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SARS-CoV-2-胎盘影响和与死产相关

Abi Merriel^1,2, Brendan Fitzgerald³, Keelin O'Donoghue^4,5

¹Centre for Women's Health Research, Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.

BJOG : an international journal of obstetrics and gynaecology

|November 20, 2023

概括

严重的COVID-19感染可能导致SARS-CoV-2胎盘炎,导致死产. 这种胎盘状况往往是亚临床的,难以预测,但可能与母亲的凝血异常有关.

科学领域:

产科和妇科产科和妇科
传染性疾病传染性疾病
病理学病理学病理学

背景情况:

随着COVID-19的流行,怀孕的结果受到了重大影响.
死产率是一个令人担忧的,但往往被忽视的结果.
新出现的证据将SARS-CoV-2感染与胎儿不良结果联系起来,特别是在阿尔法和三角洲波期间.

研究的目的:

为了检查SARS-CoV-2感染和胎盘炎之间的联系.
了解受影响怀孕中胎儿不良结果的临床表现和预测因素.
为了告知未来的管理策略,由SARS-CoV-2胎盘炎复杂的怀孕.

主要方法:

报告的SARS-CoV-2胎盘炎病例的审查.
临床数据的分析,包括母亲的症状,胎盘病理和胎儿的结果.
胎盘疾病与母亲和胎儿并发症的相关性.

主要成果:

少数COVID-19病例导致SARS-CoV-2胎盘炎,往往导致子宫内胎儿死亡.
SARS-CoV-2 胎盘炎可能是亚临床的,并不总是与严重的母体COVID-19相关.
诊断后21天内扩散的胎盘疾病,胎儿运动减少,以及母亲的血小板缺血/凝血异常与最糟糕的结果有关.

结论:

SARS-CoV-2 胎盘炎是一种严重的并发症,即使没有严重的母亲疾病,也可能导致死产.
早期识别风险因素,如胎儿运动减少和母体凝血问题至关重要.
需要多学科的合作和明确的临床指导来减少胎儿死亡. 在随后的怀孕中复发不太可能.

关键词:

这就是SARS-CoV-2病毒.胎盘组织病理学的胎盘.一个死产的死产.

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