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中性粒细胞反应强度和未成熟粒细胞的错误分类

Elias Frost Wiwe¹, Isabella Katarina Kofoed^1,2, Muriel Julie Falk Dufréchou^1,2

¹Department of Clinical Biochemistry, Nordsjaellands Hospital, University of Copenhagen, Copenhagen, Denmark.

International journal of laboratory hematology

|November 20, 2023

概括

高中性粒细胞反应强度 (NEUT-RI) 值可以在Sysmex分析仪上显示低估的不成熟颗粒细胞百分比 (IG%). 然而,仅凭NEUT-RI,除了现有的Sysmex标志之外,仅为识别这些错误提供了有限的附加价值.

科学领域:

血液学血液学血液学
临床病理学临床病理学
实验室医学实验室医学

背景情况:

未成熟颗粒细胞百分比 (IG%) 是控制感染的关键生物标志物.
自动化血液学分析仪,如Sysmex XN系列,有时可以低估IG%.
这种低估与中性粒细胞反应强度 (NEUT-RI) 值的升高有关.

研究的目的:

评估NEUT-RI是否可以选错误分类的IG%结果.
在Sysmex分析仪上确定NEUT-RI对IG%低估的预测值.

主要方法:

一项三阶段研究,包括手动涂抹分析和与自动化Sysmex IG%结果进行比较.
根据NEUT-RI值和Sysmex标志,如"异常白血细胞散射图"来选择样本.
对NEUT-RI ≥56光强度 (FI) 的评估,以预测错误分类.

主要成果:

对于IG%的错误分类,NEUT-RI ≥56 FI显示了91%的灵敏度和88%的特异性,特别是在"异常白血细胞散射图"标志下.
"异常WBC散射图"标志发现了90.1%的错误分类结果.
与目前的涂抹规则相比,NEUT-RI ≥56 FI具有较低的积极预测值 (<1%).

结论:

无论是NEUT-RI还是"异常WBC散射图"的标志都有效地识别IG%的错误分类.
除了现有实验室协议之外,NEUT-RI ≥56 FI并没有为错误分类提供显著的额外预测价值.

关键词:

不同的白血球数量.血液学测试血液学测试血液学测试中性粒细胞中性粒细胞.患者安全患者安全质量保证质量保证质量保证

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