在患有易怒肠综合征的患者中选非乳性质敏感性
Anam Ahmed1, Kunal Dixit2, Alka Singh1
1Department of Gastroenterology and Human nutrition, All India Institute of Medical Sciences, New Delhi, India.
概括
抗胺抗体 (AGA) 查在12.4%的IBS患者中发现了对质的敏感性. AGA可以作为非乳性质敏感性 (NCGS) 诊断的生物标志物,有助于临床实践.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 饮食科学 饮食科学
背景情况:
- 由于缺乏特定的生物标志物,诊断非乳性质敏感性 (NCGS) 是一个挑战.
- 目前的诊断依赖于无质饮食 (GFD) 后症状改善.
研究的目的:
- 评估抗胺抗体 (AGA) 作为选质敏感性潜在的生物标志物,在刺激性肠综合征 (IBS) 患者.
- 评估GFD和质再挑战在确认NCGS中的有效性.
主要方法:
- 使用特定抗体对492名IBS成年患者进行了乳病和谷蛋白敏感性查.
- 阳性AGA患者接受了为期6周的GFD,然后如果症状有所改善,则重新挑战质.
- 通过在质再挑战时症状复发来确认NCGS诊断.
主要成果:
- 在12.4%的IBS患者中发现了AGA阳性.
- 在GFD患者中,54.8%的患者有完整的症状反应,32.2%的患者有部分症状反应.
- 所有完全响应者在重新挑战质后证实了NCGS,并观察到AGA水平下降.
结论:
- 显著比例的IBS患者表现出生物证据的质/小麦敏感性.
- 作为NCGS的查生物标志物,AGA在临床环境中表现有前途.
- 建议在广泛临床采用之前进行进一步的研究,以验证AGA的作用.
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