结构和功能不对称性之间的半球合在临床无症状的带狭窄症与认知障碍中的半球合
Chenhong Fan1,2, Dan Xu3, Hao Mei1
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuchang District, 430071, Wuhan City, Hubei Province, China.
Brain imaging and behavior
|November 20, 2023
概括
严重无症状大脑管狭窄症 (SACS) 与大脑活动不对称性有关. 一项名为ALFF_AI的新测量结果显示,SACS患者的大脑活动下降,结构功能合发生变化.
科学领域:
- 神经成像是一种神经成像.
- 脑血管疾病 脑血管疾病
- 认知神经科学 认知神经科学
背景情况:
- 先进的动脉狭窄是缺血性中风和血管痴呆的重要危险因素.
- 它与认知障碍和大脑结构和功能的不对称变化有关.
研究的目的:
- 引入和验证一种新的测量方法,即低频波动幅度的不对称指数 (ALFF_AI),用于评估半球功能不对称.
- 调查严重无症状大脑管狭窄症 (SACS) 患者的功能性大脑不对称变化.
- 探索频率特异性变化以及SACS中的结构和功能不对称之间的合.
主要方法:
- 使用静止状态功能磁共振成像 (fMRI) 来得出ALFF_AI测量值.
- 应用高维注册来捕捉大脑内在活动的半球不对称性.
- 在不同的频率上分析了ALFF_AI并检查了结构功能合,将发现与认知测试和白质超强度负担相关联.
主要成果:
- 在SACS患者中,视觉,听觉,副海马,罗兰迪克和上顶部区域的ALFF_AI显著下降.
- 随着频率的增加,在低频率 (0.01-0.25 Hz) 观察到ALFF_AI中显著的群体差异.
- SACS患者在前额,前额,部,部和条纹体区域的结构功能合减少,但在部区域的合增加.
结论:
- 严重的无症状大脑管狭窄与大脑内在活动的不对称半球配置有关.
- 患有SACS的患者表现出结构和功能不对称性之间的脱,可能是由于血液动力学负担.
- ALFF_AI测量提供了一个敏感的工具,用于检测SACS.中的功能性大脑变化.
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