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Updated: Jul 10, 2025

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
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一个GDNF-GFRα1突触粘附组件的架构和调节

F M Houghton1, S E Adams1,2, A S Ríos3

  • 1Signalling and Structural Biology laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.

Nature communications
|November 21, 2023
PubMed
概括

质细胞系衍生神经营养因子 (GDNF) 与GFRα1形成一个十度组合,独立于RET信号传递,调解细胞粘附. 这种结构揭示了GDNF-GDNF-GFRα1复合体如何驱动膜粘附.

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