多巴胺受体激活在灵长类前额神经元的认知控制过程中调节奖励期望信号
Torben Ott1,2, Anna Marlina Stein3, Andreas Nieder4
1Animal Physiology, Institute of Neurobiology, Auf der Morgenstelle 28, University of Tübingen, 72076, Tübingen, Germany. torben.ott@bccn-berlin.de.
Nature communications
|November 21, 2023
概括
多巴胺受体刺激对前额叶皮层的奖励期望有不同的影响. 这表明多巴胺.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 多巴胺信号传递
背景情况:
- 多巴胺神经元参与奖励预测和前额叶皮层 (PFC) 功能.
- 多巴胺在PFC中调节奖励期望信号的作用,这对于认知控制至关重要,仍然不清楚.
研究的目的:
- 为了调查多巴胺是否控制奖励,PFC中的预期信号激发了认知控制的动机.
- 检查多巴胺D1受体 (D1R) 和D2受体 (D2R) 刺激对PFC中奖励期望编码的差异效应.
主要方法:
- 两只雄性 perform一个工作记忆任务与可变的奖励大小.
- 在横向PFC中记录了神经活动.
- 多巴胺D1和D2受体被使用微离子泳刺激.
主要成果:
- 许多PFC神经元在整个任务中预测了奖励大小.
- D1R刺激对奖励暗示反应产生了混合的影响,但在记忆延迟期间减少了奖励期望.
- 在多个任务期间,D2R刺激增强了奖励期望编码.
- D1R和D2R刺激都增加了神经元对交付时奖励大小的反应.
结论:
- 多巴胺受体在PFC中差异调节奖励期望信号.
- 多巴胺对奖励期望的调节对于成功的认知控制至关重要.
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