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电疗法诱导的大脑体积变化在抑郁症中汇聚在一个共同的因果回路上

Miklos Argyelan^1,2, Zhi-De Deng^3,4, Olga Therese Ousdal^5,6

¹Feinstein Institutes for Medical Research, Institute of Behavioral Science, Manhasset, NY, USA. margyela@northwell.edu.

Molecular psychiatry

|November 21, 2023

概括

电疗法 (ECT) 对常见的因果性抑郁网络 (CDN) 产生影响,类似于其他神经刺激方法,如跨磁刺激 (TMS) 和深度大脑刺激 (DBS). 优化这个网络可能会改善抑郁症治疗结果.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

神经刺激是主要抑郁症的关键治疗方法,TMS和DBS等技术针对特定的神经网络.
之前的研究发现了一个常见的因果抑郁网络 (CDN),与TMS和DBS的治疗反应有关.

研究的目的:

调查电疗法 (ECT) 是否也能调节这种CDN.
分析ECT患者的神经成像数据,以确定与抗抑郁药结局相关的CDN内的变化.

主要方法:

主要成分分析 (PCA) 用于在三个ECT队列 (N=246,79,61) 中对皮层和皮层下体积变化和电场 (EF) 分布进行了分析.
数据驱动的,无监督的多变量神经成像分析探索了CDN内的变化.
评估了与临床结果的空间相似性和相关性.

主要成果:

在三个ECT队伍中观察到CDN内部非常相似的变化模式,尽管电极放置有差异.
识别的模式显示了与TMS和DBS调节的网络具有显著的空间相似性 (r=0.65,0.58,0.40).
这种CDN模式的表达与临床抗抑郁药结局有显著的相关性 (t=-2.35,p=0.019).

结论:

与其他神经刺激方式一样,ECT汇聚在一个共同的因果抑郁网络 (CDN) 上.
这些发现支持CDN作为各种抑郁症干预措施的共同目标.
优化CDN的调制有望改善抑郁症治疗中的神经刺激结果.

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