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Updated: Jul 10, 2025

Author Spotlight: Advancements in iPSCs and Genetic Disease Research
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Author Spotlight: Advancements in iPSCs and Genetic Disease Research

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介酶干细胞分化中的表转录学修饰:进展,机械学见解,及其他方面

Jiarong Zheng1,2, Ye Lu2, Yunfan Lin2

  • 1Department of Dentistry, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.

Cell death and differentiation
|November 21, 2023
PubMed
概括

RNA修饰或表体转录组调节介酶干细胞 (MSCs). 了解这些RNA变化及其酶为MSC功能和再生医学疗法提供了洞察力.

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Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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