孕产妇感染对极度早产婴儿结果的影响
Christina L Herrera1,2, Priyanka S Kadari3, Jessica E Pruszynski4
1Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA. christina.herrera@utsouthwestern.edu.
Pediatric research
|November 21, 2023
概括
孕产妇感染并没有增加极度早产婴儿神经发育障碍或死亡的风险. 然而,急性组织学胆膜炎与这些易受伤害的婴儿的不良结果有关.
科学领域:
- 新生儿科学 新生儿科学
- 围产儿医学 围产儿医学
- 儿科神经学 儿科神经学
背景情况:
- 极度早产 (EPT) 婴儿 (妊娠29周以下) 面临高发病和死亡风险.
- 孕产妇感染是EPT婴儿不良神经发育结果的潜在贡献者.
- 这项研究调查了EPT婴儿在母亲感染和神经发育障碍 (NDI) 或2岁死亡之间的关联.
研究的目的:
- 为了确定母亲的子宫外或子宫内感染是否与NDI或EPT婴儿2岁死亡有关.
- 探索胎盘病理之间的关系,特别是急性组织学肌膜炎,以及EPT婴儿的NDI或死亡.
- 为极度早产新生儿影响结果的因素提供见解.
主要方法:
- 在2010年1月至2020年12月期间出生的548名EPT婴儿进行了回顾性队列研究.
- 提取了母亲感染数据 (子宫外和子宫内) 和胎盘病理.
- 主要结局:NDI或2岁时死亡.
主要成果:
- 在母亲的子宫外或子宫内感染与NDI或2年后死亡之间没有发现显著的关联 (p > 0.05).
- 急性组织学膜炎与NDI或2年后死亡风险增加显著相关 (p = 0.033).
- 孕产妇感染似乎不是这个队列中不良结果的直接驱动因素.
结论:
- 一般来说,母亲感染与极度早产婴儿的不良神经发育结果或死亡无关.
- 急性组织学膜炎是一种胎盘炎症,已成为EPT婴儿不良结果的重要危险因素.
- 需要进行进一步的研究,以阐明感染和免疫反应在急性组织学肌炎中的特定作用及其对EPT婴儿结局的影响.
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