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Updated: Jul 8, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

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空间宿主-微生物组测序揭示了小鼠肠道中的

Britta Lötstedt1,2,3, Martin Stražar4, Ramnik Xavier4,5,6

  • 1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nature biotechnology
|November 21, 2023
PubMed
概括

一种新的方法,空间宿主-微生物组测序 (SHM-seq),映射组织中的宿主细胞和微生物. 这揭示了肠道细胞和细菌在特定的空间中如何相互作用,进步了我们对共生和疾病的理解.

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Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
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