阻塞性睡眠呼吸暂停综合征与恐慌症并发症中的血清C反应蛋白水平和睡眠特征:一项初步研究
Shuai Yang1,2, Xiaoyi Kong2, Xueyan Li2
1Department of Neurocritical Care Unit, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, P. R. China.
BMC psychiatry
|November 21, 2023
概括
患有阻塞性睡眠呼吸暂停综合征和恐慌症患者的睡眠质量较差,C反应性蛋白水平较低. 这些CRP水平与睡眠障碍相关,而不是呼吸暂停的严重程度.
科学领域:
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
- 心血管健康 心血管健康
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 和恐慌障碍 (PD) 是常见的疾病.
- OSAS和PD的并发症可能会影响睡眠特征和炎症标志物.
- C-反应蛋白 (CRP) 是系统性炎症的标志物.
研究的目的:
- 为了研究与PD并发性OSAS患者的睡眠特征.
- 探索这些患者的睡眠参数和血清CRP水平之间的关联.
- 为了比较患有PD和没有PD的OSAS患者之间的睡眠质量和CRP水平.
主要方法:
- 纳入了54名患有OSAS的患者 (25名患有PD,29名没有PD) 和25名健康对照 (HCs).
- 心理测量评估包括自我评价焦虑量表 (SAS),自我评价抑郁量表 (SDS) 和匹兹堡睡眠质量指数 (PSQI).
- 在所有参与者身上测量了多睡眠图和血清CRP水平.
主要成果:
- 患有PD的OSAS患者报告了更糟糕的焦虑,抑郁和睡眠质量 (更高的SAS,SDS,PSQI).
- 与没有PD的OSAS相比,PD的OSAS显示了睡眠架构的改变 (更高的N1/N2%,更低的REM%) 和较不严重的OSAS指标 (更低的AHI,T90,更高的LO2).
- 血清CRP水平在PD的OSAS中低于没有PD的OSAS,但高于HCs. CRP与觉醒时间和SAS有负相关性,与睡眠效率和N2%以及低氧持续时间 (T90,LO2) 有正相关性.
结论:
- 患有与PD并发症的OSAS患者的睡眠质量较差,OSAS的严重程度较小.
- 血清CRP水平在患有PD的OSAS患者中较低,与睡眠质量和缺氧持续时间有关,而不是呼吸暂停-缺氧指数 (AHI).
- 这些发现表明睡眠,焦虑和炎症之间的复杂相互作用在伴随性OSAS和PD中.
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