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在患有注意力缺陷/多动症障碍的儿童中,潜在的自闭症特征是特定的大脑成像变化

Juan Liu¹, Qian-Rong Liu², Zhao-Min Wu¹

¹Children's Healthcare and Mental Health Center, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.

Behavioral and brain functions : BBF

|November 21, 2023

概括

患有注意力缺陷/多动障碍 (ADHD) 的儿童的自闭症特征 (AT) 与更大的行为障碍和独特的大脑活动模式有关. 在ADHD中识别AT可以阐明ADHD异质性并指导干预.

科学领域:

神经科学是一个神经科学.
儿童心理学儿童心理学
发育障碍发育障碍发展障碍

背景情况:

自闭症特征 (AT) 经常在被诊断为注意力缺陷/多动障碍 (ADHD) 的儿童中观察到.
了解AT和ADHD之间的相互作用对于理解ADHD的异质性至关重要.

研究的目的:

在患有注意力缺陷/多动症障碍 (ADHD) 的儿童中调查自闭症特征 (AT).
区分与ADHD中AT相关的行为和神经成像特征.
为了探索ADHD的脑行为关系,有或没有ATS.

主要方法:

使用自闭症谱查问卷 (ASSQ) 来对参与者进行分类.
招募了三个组:具有AT的ADHD (ADHD+ATs),没有AT的ADHD (ADHD-ATs) 和健康的对照 (HC-ATs).
收集了静止状态功能磁共振成像 (rs-fMRI) 数据,以分析低频波动 (mALFF) 值的平均幅度.

主要成果:

与ADHD-ATs组相比,ADHD+ATs组表现出更多的全球自闭症症状和更高的多动/冲动 (HI).
过度活跃/冲动 (HI) 与ADHD儿童的AT的各个方面有显著的相关性.
神经成像揭示了与ADHD相关的独特大脑区域 (左侧MOG,PL/precuneus,MTG) 和ATs (右侧MTG),与右侧PL/precuneus的共同变化.

结论:

在ADHD中ATs的同时出现呈现出独特的行为和大脑功能配置文件.
评估ADHD儿童的ATS对于理解ADHD的复杂性质至关重要.
这项研究通过澄清ADHD异质性,支持量身定制的临床干预措施.

关键词:

更多关于 ADHD ADHD 的文章自闭症特征自闭症特征行为行为行为.休息状态的功能性MRI.

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