IBD-FITT研究 - 适度强度炼患者的炎症性肠病与中度疾病活动:一个开放的标签随机对照试验
Ken Lund1,2, Torben Knudsen3,4, Jens Kjeldsen5,6
1Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark. ken.lund@rsyd.dk.
Trials
|November 21, 2023
概括
这项临床试验调查了12周的运动计划对炎症性肠病 (IBD) 患者的影响. 结果可能会显示运动作为克罗恩病和性结肠炎管理的有益补充治疗.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 运动生理学 运动生理学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,包括需要终身治疗的慢性自身免疫性疾病.
- 目前的治疗方法,包括药物治疗和手术,缺乏确定的治疗方法,强调了需要补充治疗策略的需要.
- 身体活动和炼在IBD预防和管理方面显示出潜力,但由于试验数据有限,需要进一步调查.
研究的目的:
- 评估12周有氧运动干预措施对中度活跃IBD的成年患者的疗效.
- 评估运动对疾病特异性生活质量 (IBDQ),一般健康状况和免疫生物标志物的影响.
- 探索运动作为一种潜在的补充治疗,以改善患者的治疗结果和生活质量.
主要方法:
- 一个优越的,开放的,随机的临床试验,涉及150名IBD患者,均分为干预和控制组.
- 干预组将接受一个为期12周的计划,包括两个监督的60分钟的有氧练习和一个每周一次的家庭练习,其最大心率为60-80%.
- 结果将使用验证的问卷 (IBDQ,EQ5D),临床评估 (疾病活动指数,人体测量,血压,脂质) 和生物标志物分析 (CRP,便calprotectin,细胞因子) 来测量.
主要成果:
- 数据收集包括在基线和研究结束时使用生活质量调查问卷.
- 生物标志物和临床数据将在基线,第4周和第8周以及研究完成时收集.
- 这项研究旨在提供关于炼对IBD患者影响的可靠数据.
结论:
- 这项临床试验将提供有关运动在克罗恩病和性结肠炎管理中的作用的证据.
- 这些发现可能会澄清运动作为IBD辅助治疗的益处.
- 这项研究旨在引入一种新的,以患者为中心的方法,通过身体活动来管理疾病.
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