相关实验视频
Updated: Jul 10, 2025
08:56
Study of Experimental Organ Donation Models for Lung Transplantation
Published on: March 15, 2024
1.7K
与COVID-19死亡相关的器官和系统与器官支持信息:一个多中心观察性研究
Ryuichi Nakayama1, Naofumi Bunya2, Takashi Tagami3,4
1Department of Emergency Medicine, Sapporo Medical University School of Medicine, 291, Minami 1-jo Nishi 16-chome, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
BMC infectious diseases
|November 21, 2023
概括
呼吸系统功能障碍是COVID-19患者的主要死亡原因. 然而,多器官功能障碍也对这些病例的死亡率有显著的贡献,凸显了疾病的复杂性.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 临界护理医学 临界护理医学
背景情况:
- 在大规模研究中,导致COVID-19患者死亡的特定器官功能障碍仍然不清楚.
- 需要进行多中心流行病学研究,以确定COVID-19中死亡率的主要驱动因素.
研究的目的:
- 为了评估COVID-19患者与死亡相关的主要器官功能障碍.
- 为了确定COVID-19死亡中多个器官衰竭的比例.
- 在致命的COVID-19病例中分析器官支持信息.
主要方法:
- 使用日本多中心研究COVID-19 (J-RECOVER) 数据库进行了观察性队列研究.
- 分析了2020年1月1日至9月30日期间出院的4700名患者的数据.
- 临床医生确定了272名已故COVID-19患者死亡的主要器官.
主要成果:
- 呼吸系统功能障碍是导致死亡的主要原因 (87.1%),其次是心血管 (4.8%) 和中枢神经系统 (2.9%) 的功能障碍.
- 几乎所有去世的患者 (96.7%) 患有呼吸系统损伤,近一半 (48.9%) 患有多器官损伤.
- 机械通风在50.6%的患者中使用,其主要死亡原因是呼吸功能障碍.
结论:
- 呼吸系统功能障碍是与COVID-19死亡率相关的最常见的器官衰竭.
- 多器官功能障碍是导致COVID-19患者死亡的重要因素.
相关概念视频
01:30Pneumonia III: Complications and Assessment
240
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
240
01:29Pneumonia II: Pathophysiology
287
The pathophysiology of pneumonia involves the following steps:
287
01:30Acute Respiratory Failure-III
187
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
187
01:21Acute Respiratory Failure-II
243
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
243
01:21Acute Respiratory Failure-I
216
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
216
01:20COPD: Pathogenesis and Clinical Features
294
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
294