危急病患者的替代性氨酸- ангиотензин系统:病理生理学和治疗影响
Bruno Garcia1,2,3, Alexander Zarbock4, Rinaldo Bellomo5,6,7
1Department of Anesthesia and Peri-Operative Care, Division of Critical Care Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Critical care (London, England)
|November 21, 2023
概括
替代性氨酸- ангиотензин系统 (RAS),包括ACE2和 ангиотензин-1-7),在危急疾病中至关重要. 调节这个系统为重症患者提供了潜在的治疗益处.
科学领域:
- 心血管研究研究心血管研究
- 脏生理学 脏生理学
- 关键护理医学 关键护理医学
背景情况:
- 经典的胺-血管酶系统 (RAS) 在危急疾病中发生变化,影响血压和心功能.
- 涉及ACE2和血管素-1-7的替代RAS在对抗古典RAS方面发挥着关键作用.
- 诸如二乙酶3之类的成分与冲击,急性损伤和死亡率有关.
研究的目的:
- 审查RAS的分析方法.
- 在重症患者中探索RAS内的病理生理学障碍.
- 讨论针对替代RAS的治疗策略,以改善患者的治疗结果.
主要方法:
- 对RAS分析和重症监护中的功能现有文献的审查.
- 对替代RAS组件的临床前和临床研究进行审查.
- 综合关于病理生理学作用和治疗潜力的证据.
主要成果:
- 替代RAS,特别是ACE2和血管素-1-7),在败血症和急性肺损伤的实验模型中显示出保护作用.
- 目前正在探索与冲击相关的并发症的二乙酶3抑制.
- ангиотензин-(1-7) 在败血症模型和COVID-19低氧症中表现有前途.
结论:
- 替代RAS在关键疾病的发病过程中起着重要作用.
- 替代RAS的治疗调节为改善重症患者的治疗结果提供了一个有希望的途径.
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