佩普西诺基因比率和腕脉冲波速率:对它们在动脉样硬化中的相互关系进行横截面研究
Yuexi Li1, Xiaoqin Liu2, Yuhan Luo1
1Health Management Center, Deyang People's Hospital, No. 173, Taishan North Road, Deyang City, Sichuan Province, China.
BMC cardiovascular disorders
|November 21, 2023
概括
素因子比率 (PGR) 与动脉硬性 (baPWV) 有非线性联系. 较低的PGR水平与baPWV有很强的反相关性,这表明它是动脉样硬化的潜在治疗标.
科学领域:
- 心血管医学 心血管医学
- 生物标志物研究 生物标志物研究
- 胃肠病学 胃肠病学
背景情况:
- 素因子比 (PGR) 是胃肠道疾病的已知生物标志物,与动脉样硬化心血管疾病有关.
- 将PGR与心血管病理联系在一起的确切机制尚未完全理解.
- 腕脉冲波速度 (baPWV) 是动脉硬和动脉样硬化进展的关键指标.
研究的目的:
- 量化研究PGR和baPWV之间的关联.
- 阐明PGR与动脉样硬化进展指标之间的关系.
主要方法:
- 一项对465名接受健康检查的患者进行的横截面研究.
- 使用ANOVA对baPWV潜在风险因素的分析.
- 多重后勤回归以评估PGR作为高baPWV的独立风险因素.
- 一般化的增材模型和光滑曲线拟合,以探索非线性关联并确定拐点.
主要成果:
- 在对混因素进行调整后,PGR与右侧baPWV (RbaPWV) 和左侧baPWV (LbaPWV) 显示出显著的负相关性.
- 观察到非线性关系,PGR值的拐点为22.5 (RbaPWV) 和22.3 (LbaPWV).
- 较低的PGR水平 (<22.5或<22.3) 与baPWV有强烈的反向相关,而较高的水平没有显著的线性关系.
结论:
- PGR与动脉硬性 (baPWV) 有非线性联系.
- 较低的PGR水平与baPWV相反相关,这表明它可能在动脉样硬化中发挥作用.
- 调节PGR水平可能是治疗动脉样硬化的新疗法策略.
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