在使用L-甲氧氨酸的患者中评估下的皮质和骨骨结构
Melike Gulec1, Melek Tassoker2, Mediha Erturk3
1Department of Dentomaxillofacial Radiology, Karamanoğlu Mehmetbey University Faculty of Dentistry, Karaman, Turkey.
BMC oral health
|November 21, 2023
概括
长期使用L-thyroxine (LT4) 会影响下皮层骨,但不会影响椎骨密度. 这项研究发现,LT4使用者和对照者之间的下皮质指数 (MCI) 分数存在显著差异,这表明潜在的骨变化.
科学领域:
- 内分泌学和骨代谢 骨质代谢
- 牙科放射学和口腔健康
- 医学成像分析 医学成像分析
背景情况:
- 长期的L-甲状腺素 (LT4) 治疗是一种常见的甲状腺功能低下症治疗方法,是骨质疏松症的已知危险因素.
- 研究LT4对下骨质量的影响对于了解系统性骨健康至关重要.
- 全景放射提供了一种非侵入性的方法来评估下骨的特征.
研究的目的:
- 为了比较使用LT4与对照的女性患者的下皮质指数 (MCI) 和骨骨碎片尺寸 (FD).
- 评估LT4使用与下骨结构的特定指数之间的关联.
主要方法:
- 一项涉及142名女性患者的病例控制研究 (71名LT4用户,71名对照),年龄 (18-50岁) 匹配.
- 皮皮质指数 (MCI) 得到得分 (C1-C3),并使用碎形分析 (盒子计数方法) 来从全景放射图中确定椎骨碎形尺寸 (FD).
- 统计分析包括威尔科克森签名等级,曼-惠特尼U和斯皮尔曼相关性测试 (P <0.05).
主要成果:
- 在分析的任何区域中,在LT4使用者和对照者之间没有统计学上显著的差异 (p > 0.05).
- 皮皮质指数 (MCI) 分数在各组之间有显著差异 (p = 0.016).
- 在LT4组中,中度吸收下巴皮层 (C2) 的患病率更高,而对照组主要显示下巴皮层 (C1) 正常.
结论:
- 长期使用L-thyroxine (LT4) 与下皮层骨质量 (MCI) 的变化有关,但与状骨结构 (FD) 的变化无关.
- 这些发现凸显了LT4治疗对口腔骨健康的特定方面可能产生的影响.
- 建议对更大的队列和各种成像技术进行进一步的研究,以阐明这些关联.
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