步行节奏和手握强度与慢性阻塞性肺病风险的关联:双向的门德尔随机化研究
Peng Qiu1, Mingxian Chen2, Shuaibing Lv3
1Department of Rehabilitation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
BMC pulmonary medicine
|November 21, 2023
概括
更快的步行速度 (WP) 与慢性阻塞性肺部疾病 (COPD) 的风险降低有关. 相反,下手握力 (HGS) 与COPD风险增加有关,这表明WP是潜在的预测因素.
科学领域:
- 遗传学和流行病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 慢性阻塞性肺病 (COPD) 是全球主要的死亡原因.
- 步行速度 (WP) 和手握力 (HGS) 是已确定的健康指标.
- 需要进一步澄清WP,HGS和COPD风险之间的关系.
研究的目的:
- 调查WP,HGS和COPD风险之间的因果关系.
- 使用孟德尔随机化 (MR) 探索这些因素之间的双向关系.
主要方法:
- 双向门德尔随机化 (MR) 分析.
- 利用了来自欧洲个人的全基因组关联研究 (GWAS) 数据.
- 采用逆变量加权 (IVW) 作为主要方法,并补充了灵敏度分析和多变量MR (MVMR).
主要成果:
- 在WP和COPD风险之间发现了显著的逆因果关系 (OR=0.21,P=5.06×10−4).
- 反向MR分析表明,COPD也对WP产生负面影响.
- 降低COPD风险与右上HGS相关 (OR=0.74,P=1.44×10−2),尽管主要是在二次分析中.
结论:
- 步行速度和COPD风险之间存在双向因果关系.
- 减少手握强度是单向与增加的COPD风险相关的.
- 步行速度可以作为COPD的预后指标.
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