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TarBase-v9.0将实验支持的miRNA-基因相互作用扩展到细胞类型和病毒编码的miRNA

Giorgos Skoufos^1,2, Panos Kakoulidis^3,4, Spyros Tastsoglou^1,2

¹DIANA-Lab, Dept. of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.

Nucleic acids research

|November 21, 2023

概括

现在TarBase v9.0包括病毒微RNA (miRNA) 和目标导向的miRNA降解 (TDMD) 事件. 这种扩展的数据库提供了数以百万计的经过实验验证的miRNA-基因相互作用在不同的生物环境.

科学领域:

分子生物学分子生物学
基因组学就是基因组学.
生物信息学是一种生物信息学.

背景情况:

微RNAs (miRNAs) 是基因表达的关键调节者.
准确的miRNA目标数据库对于生物研究至关重要.
以前的TarBase版本提供了经过实验验证的miRNA目标.

研究的目的:

介绍最新版本的TarBase (v9.0),一个全面的实验支持miRNA目标的数据库.
扩展数据库以新的内容,包括病毒miRNA和目标导向miRNA降解 (TDMD) 事件.
为了提高数据库的可用性和数据检索能力.

主要方法:

来自不同来源的精选和整合经过实验验证的miRNA-基因相互作用.
结合了病毒miRNA和TDMD事件的数据.
开发了一个重新设计的网络界面,具有高级查询和过选项.

主要成果:

TarBase v9.0包含大约600万条条目,包括约200万个独特的miRNA-基因对.
该数据库涵盖了172个组织和细胞类型的37个实验协议.
丰富的元数据和数以百万计的miRNA结合位置提供了细胞类型分辨率.

结论:

TarBase v9.0代表了miRNA目标信息的范围和深度的显著扩展.
增强的界面可以促进复杂的数据探索和分析.
这个更新的资源支持miRNA生物学和基因调节的先进研究.

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