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Updated: Jul 10, 2025

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在超越5规则空间中平衡脂性和透性的设计原则

Henrik Möbitz1

  • 1Computer-Aided Drug Design, Global Discovery Chemistry, Novartis BioMedical Research, 4002, Basel, Switzerland.

ChemMedChem
|November 21, 2023
PubMed
概括

口服药物的新设计原则超出了规则5 (bRo5) 规则的药物平衡脂性和透性. 这些原则,包括拓极地表面积 (TPSA) /分子量 (MW) 范围和3D PSA,提高bRo5药物发现的口服生物可用性.

关键词:
在 Ab initio 计算过程中,吸收方式 吸收方式对形状分析的分析.药物设计 药物设计脂友性 脂友性 脂友性

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