血管内皮生长因子-D血水平在流体过载和心脏功能评估的老年患者心血管疾病的血水平

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Jun Li^1,2, Xiao-Lin Li², Fa-Hu Liu³

¹Department of Nephrology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.

Medicine

|November 21, 2023

概括

血管内皮生长因子-D (VEGF-D) 和生长差异化因子-15 (GDF-15) 在老年心血管患者中表现为流体过载和心脏功能的生物标志物. 较高的VEGF-D水平与心力衰竭严重程度和心脏功能指标相关.

科学领域:

心脏病学心脏病学
生物标志物发现发现
老年医学老年医学

背景情况:

老年人的心血管疾病 (CVD) 在管理流体过载和评估心脏功能方面提出了复杂的挑战.
现有的生物标志物可能无法完全捕捉老年人群中心血管疾病复杂的病理生理学.

研究的目的:

研究血管内皮生长因子 (VEGF) 亚型 (VEGF-C,VEGF-D) 和生长分化因子-15 (GDF-15) 血水平的临床意义.
评估它们在评估患有心血管疾病的老年患者的流体过载和心脏功能的有用性.

主要方法:

在老年心血管疾病患者中,使用ELISA测量了VEGF-C,VEGF-D和GDF-15的血水平.
分析了与N-终端亲B型性尿素 (NT-pro BNP) 和心声学参数的相关性.

主要成果:

在心血管疾病和心力衰竭患者中观察到更高的VEGF-D和GDF-15血水平.
VEGF-D水平与NT-pro BNP和心脏功能和流体过载的心声心脏学指标正相关.
GDF-15水平与心脏和管道损伤的生物标志物相关,以及年龄,功能和营养状况.

结论:

在老年心血管疾病患者中,VEGF-D显示出作为流体过载和心脏功能生物标志物的潜力.
GDF-15和NT-pro BNP水平受到年龄,营养和功能的影响,这影响了它们在评估心脏状况时的使用.

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