肠道微生物群对橄果糖和胰岛素的反应差异是由最初的肠道Bacteroides/Bifidobacterium比率决定的
Pingping Yin1, Ting Du1, Shanrong Yi1
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Food research international (Ottawa, Ont.)
|November 21, 2023
概括
益生菌的有效性因肠道细菌的比例而异. 橄果糖 (Oligofructose,简称FOS) 对具有高菌/双菌 (Ba/Bi) 比率的个体有好处,增强了有益细菌和代谢物.
科学领域:
- 微生物学 微生物学
- 人类营养人类营养
- 胃肠病学 胃肠病学
背景情况:
- 益生菌调节肠道微生物群,但宿主反应因碳水化合物利用差异而有所不同.
- 细菌的比率与Bifidobacterium (Ba/Bi) 细菌的比率是益生菌利用的关键.
- 基于Ba/Bi比率的益生菌的差异效应仍未得到充分研究.
研究的目的:
- 调查益生菌 (橄果糖和胰岛素) 对肠道微生物群组成和功能的影响,对具有高和低Ba/Bi比率的个体进行研究.
- 探索由基线微生物群影响的前生物反应的宿主变异性.
- 为了确定不同肠道微生物特征的具体益处.
主要方法:
- 一个为期4周的随机双盲并行四臂试验.
- 两个益生菌:橄果糖 (FOS) 和胰岛素.
- 两组参与者:高的Ba/Bi比率 (H) 和低的Ba/Bi比率 (L).
主要成果:
- 益生菌的反应受到基线微生物群组成的影响.
- 橄果糖 (FOS) 通常比胰岛素更有效地调节肠道微生物群.
- 具有高Ba/Bi比率 (H) 的个体显示,生产黄油酸的细菌和与FOS.的代谢物增加.
- 对胰岛素的代谢反应不同:低的Ba/Bi (L) 增加了酸,而高的Ba/Bi (H) 显示了氨基酸代谢的丰富.
结论:
- 基线肠道微生物群组成,特别是Ba/Bi比率,显著影响益生菌的疗效.
- 橄果糖 (Oligofructose,简称FOS) 可能更有利于具有高Ba/Bi比率的个体,因为其产量增加了酸盐.
- 基于个体肠道微生物群的个人特征,推个性化的益生菌选择以获得最佳的健康益处.
相关概念视频
Bacterial Flora of the Large Intestine
473
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
473
Anatomy of the Intestines
72.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.1K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
337
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
337
Irritable Bowel Syndrome I: Introduction
280
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
280
What is Monogastric Digestion?
71.2K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.2K


