在Hibiscus sabdariffa饮料中的生物活性化合物的生物可用性作为潜在的抗炎药物
Alejandro Arce-Reynoso1, Raquel Mateos2, Edgar J Mendivil3
1Tecnológico Nacional de México/ Instituto Tecnológico de Tepic, Laboratorio Integral de Investigación en Alimentos, División de Estudios de Posgrado, Av. Tecnológico, No 2595, Col. Lagos del Country CP 63175, Tepic, Nayarit México.
Food research international (Ottawa, Ont.)
|November 21, 2023
概括
在Hibiscus sabdariffa饮料 (HbD) 中的生物活性化合物研究了生物可用性. 有机酸和化合物被吸收,其代谢物可能负责抗炎作用.
科学领域:
- 药理学和药理动力学 药理学和药理动力学
- 营养科学 营养科学
- 自然产品化学 自然产品化学
背景情况:
- Hibiscus sabdariffa 被公认为具有潜在的健康益处,通常归因于其丰富的生物活性化合物特征.
- 了解这些化合物的体内命运对于验证其治疗性要求至关重要.
研究的目的:
- 为了研究从Hibiscus sabdariffa饮料 (HbD) 中的有机酸 (OA) 和化合物 (PC) 的吸收和新陈代谢.
- 识别关键代谢物并评估它们在血和尿液中的生物可用性.
主要方法:
- 这是一项急性,单盲临床研究,涉及12名志愿者.
- 消费HbD和控制饮料 (CD),然后收集血和尿液样本.
- 使用二极管阵列检测和质谱仪 (HPLC-DAD-MS) 的高性能液态染色学用于化合物表征和量化.
主要成果:
- 在HbD (937.37 mg/60 mL) 中量化的38种化合物与CD (1.22 mg/60 mL) 中量化的4种化合物相比,Hibiscus酸是最丰富的OA.
- 类化合物 (基胺酸,黄类,氨酸) 占HbDBCs的10%.
- 确定了25种代谢物 (15种在尿液中,23种在血中),表明PCs的广泛微生物生物转化,其中OA更为突出.
结论:
- 从HbD获得的OA和PC的生物可用性在人类受试者中得到证明.
- 假设OA和PC的结肠代谢物有助于Hibiscus sabdariffa的抗炎性质.
- 需要进一步的研究,以确定负责观察到的生物活性的特定代谢物.
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