扩展的富有血小板的纤维素
Richard J Miron1,2, Michael A Pikos3, Nathan E Estrin1
1Advanced PRF Education, Jupiter, Florida, USA.
Periodontology 2000
|November 21, 2023
概括
一种新的加热过程将富含血小板的纤维素 (PRF) 转化为扩展型PRF (e-PRF),这是一个具有4-6个月再吸收周期的再生生物材料. 这种增强的e-PRF显示出作为牙科和骨科中的原膜替代品的前景.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 牙周病学和植入物牙科 牙科
背景情况:
- 富含血小板纤维素 (PRF) 是一种再生生物材料,其吸收周期短,为2-3周.
- 在各种医疗和牙科应用中,临床需要更持久的再生材料.
研究的目的:
- 审查关于扩展PRF (e-PRF) 技术的科学文献,一种新的加热PRF变种.
- 总结关于e-PRF特性和应用的临床前和临床发现.
- 探索e-PRF作为原膜替代品和再生填充剂的潜力.
主要方法:
- 使用关键词进行系统的文献综述:生物热,白蛋白凝,白蛋白PRF,Alb-PRF,扩展PRF,e-PRF,激活血白蛋白凝,APAG.
- 搜索的数据库有:MEDLINE,EMBASE,PubMed. 这些数据库的搜索内容包括:
- 包括临床前研究 (ISO 10993) 和临床案例研究.
主要成果:
- 一个10分钟的加热过程将液体白蛋白转化为凝,将再吸收延长至至少4个月 (ISO 10993临床前数据).
- 临床研究表明,e-PRF膜可以作为引导性骨再生 (GBR),鼻提升和衰退覆盖中的原膜的替代品.
- 由于其延长的持续时间,Alb-PRF显示出作为可注射填充剂的潜力,用于关节注射,骨关节炎和面部美学.
结论:
- 与传统的PRF相比,新的Alb-PRF/e-PRF技术显著提高了稳定性和降解性能.
- 在各种牙科和骨科手术中,e-PRF显示出广泛的潜力,作为成本效益高,天然替代原膜的替代品.
- 鼓励对Alb-PRF/e-PRF进行进一步的研究,以应用于其作为再生填充剂和生物材料的应用.
相关概念视频
Formation of the Platelet Plug
6.5K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.5K
Clot Retraction and Fibrinolysis
6.2K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.2K
Structure and Function of Platelets
1.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.2K
Introduction to Hemostasis
8.1K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.1K


