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培养阳性新生儿败血症的10天与14天的抗生素治疗
Kamirul Islam1, Nazima Khatun2, Kuntalkanti Das1
1Department of Pediatrics, Burdwan Medical College, Burdwan 713104, West Bengal, India.
Journal of tropical pediatrics
|November 21, 2023
概括
新生儿败血症的10天抗生素治疗与14天治疗一样有效. 这种较短的持续时间导致培养阳性败血症婴儿的住院时间减少,而不会增加不良影响.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 临床试验 临床试验
背景情况:
- 新生儿败血症显著导致婴儿死亡率.
- 对培养阳性败血症抗生素持续时间的基于证据的指导方针是有限的.
研究的目的:
- 为了比较10天和14天的抗生素治疗对培养阳性新生儿败血症的疗效.
主要方法:
- 一项随机对照试验在第三级护理NICU中进行.
- 234名具有培养阳性败血症的新生儿被随机分配给接受10天或14天的抗生素.
- 评估的结果包括治疗失败,住院和不良反应.
主要成果:
- 乙杆菌是最常见的病原体 (23.9%).
- 治疗失败率在10天和14天组之间是相似的 (3.8%对1.7%).
- 10天组的住院时间显著缩短 (14天 vs. 18天).
结论:
- 十天的抗生素治疗效果与新生儿败血症的14天治疗效果相当.
- 较短的抗生素疗程可以减少住院时间,而不会增加不良事件.
- 这支持更短的抗生素持续时间在管理培养阳性新生儿败血症.
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